Abiraglob (abiraterone acetate 250mg) is a prescription oral medication classified as an androgen biosynthesis inhibitor. It works by blocking the enzyme CYP17, which significantly reduces androgen (male hormone) production in the body—including in the testes, adrenal glands, and prostate tumor cells. This helps slow or stop the growth of prostate cancer cells that rely on androgens to proliferate.
In Nigeria, Abiraglob is a cost-effective generic equivalent to brand-name Zytiga, commonly prescribed for men with metastatic castration-resistant prostate cancer (mCRPC) who are asymptomatic or mildly symptomatic after failure of androgen deprivation therapy (ADT). It's often used in combination with low-dose prednisone or prednisolone to manage side effects. Available through trusted pharmacies like Sanlive in Lagos, it's NAFDAC-registered and supports long-term management under oncologist/urologist supervision.
Important: This is a prescription-only medication. A valid doctor's prescription is required for purchase and dispensing.
Abiraglob (Abiraterone Acetate) is primarily used to:
It provides systemic hormonal control for advanced prostate cancer, often improving outcomes when added to ongoing ADT.
Abiraglob is indicated for:
Not recommended for: Women (including pregnant/breastfeeding—poses risk to male fetus; women of childbearing potential should not handle tablets without gloves), children, men with severe liver impairment, uncontrolled hypertension, heart failure, or known hypersensitivity. Avoid if recent or active severe cardiovascular issues without specialist approval. Consult your oncologist before starting, especially if you have diabetes, mineralocorticoid excess symptoms, or take other medications.
Suggested Dosage: Typically 1000 mg (four 250mg tablets) once daily on an empty stomach (at least 1 hour before or 2 hours after food), taken with prednisone/prednisolone as prescribed. Swallow whole with water. Your doctor will monitor liver function, blood pressure, potassium, and PSA regularly.
Abiraglob is generally manageable, but common side effects (often due to mineralocorticoid effects or low cortisol) include:
Serious risks include severe liver toxicity (monitor LFTs), heart problems, adrenal insufficiency, or fractures. Report symptoms like severe fatigue, swelling, rapid heartbeat, yellowing skin, or unusual bleeding promptly.
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