Vfend contains Voriconazole, a high-potency, second-generation triazole antifungal. It is a critical, life-saving medication used primarily in hospital settings to treat serious, invasive fungal infections. Vfend works by inhibiting the fungal cytochrome P450-mediated 14-$\alpha$-lanosterol demethylation, a vital step in fungal cell wall synthesis. By disrupting the cell membrane, it effectively kills or stops the growth of a wide range of fungal pathogens, including those resistant to older treatments like Fluconazole.
Product Type: Triazole Antifungal (Intravenous)
Active Ingredient: Voriconazole (200mg)
Manufacturer: Pfizer (Original Brand) / Generic Equivalents Available
Pack Size: Single-use Clear Glass Vial (Powder for Solution)
Route: Intravenous (IV) Infusion Only
Availability: Strictly Prescription Required (POM) — Hospital Use Only
Suitable For: Adults and Children (over 2 years) with invasive fungal infections
Vfend is reserved for severe, systemic infections, often in immunocompromised patients:
Invasive Aspergillosis: The gold-standard treatment for this serious lung infection caused by Aspergillus molds.
Candidemia: Treating bloodstream infections caused by Candida species in non-neutropenic patients.
Invasive Candida Infections: Deep-seated tissue infections, including those resistant to Fluconazole (e.g., Candida krusei).
Serious Fungal Infections: Treating rare but deadly infections like Scedosporium and Fusarium species.
Prophylaxis: Preventing invasive fungal infections in high-risk patients (e.g., bone marrow transplant recipients).
Visual Disturbances: About 30% of patients experience temporary vision changes (blurred vision, color changes, or sensitivity to light) during or shortly after infusion. Do not drive if you experience these. Liver Toxicity: Vfend can cause serious liver damage. Your doctor must monitor your liver function tests (LFTs) weekly at the start of treatment. QT Prolongation: This medication can affect heart rhythm. Use with extreme caution if you have existing heart conditions or electrolyte imbalances. Skin Cancer Risk: Long-term use is associated with a risk of squamous cell carcinoma of the skin. Photosensitivity: Avoid intense, direct sunlight and always use high-SPF sunscreen, as Vfend makes your skin extremely sensitive to UV rays.
Vfend must be prepared and administered by a qualified healthcare professional.
Administration Protocols:
Reconstitution: The 200mg powder is first dissolved with 19ml of Water for Injection to create a $10mg/ml$ concentrate.
Dilution: This concentrate must then be further diluted in a compatible IV fluid (like 0.9% Normal Saline or 5% Dextrose) to a final concentration between $0.5mg/ml$ and $5mg/ml$.
Infusion Rate: Administer slowly via a dedicated IV line over 1 to 3 hours. Never give as a rapid "bolus" injection.
Loading Dose: Treatment usually begins with two "loading doses" 12 hours apart to reach therapeutic levels quickly, followed by a maintenance dose.
Common side effects include the visual disturbances mentioned above, fever, nausea, vomiting, diarrhea, headache, and a skin rash. Swelling of the limbs (peripheral edema) or stomach pain may also occur. If you develop a severe, peeling skin rash, yellowing of the eyes (jaundice), or sudden shortness of breath, notify the medical team immediately.
Store the unmixed vial at room temperature below 30°C. Once reconstituted, the solution should be used immediately. If necessary, it can be stored for up to 24 hours in a refrigerator ($2^\circ\text{C}$ to $8^\circ\text{C}$). Discard any unused portion. Keep out of reach of children.
Q: Can I switch to "Vfend Tablets" later?
A: Yes. Voriconazole has very high "oral bioavailability." Once a patient is stable and able to swallow, doctors often switch from the IV vial to Vfend 200mg Tablets to complete the course at home.
Q: Why are there so many "Drug Interactions"?
A: Vfend is a strong inhibitor of liver enzymes (CYP3A4). It can dangerously increase the levels of other drugs like Statins, Warfarin, or certain sedatives. Always provide a full list of your medications to our pharmacist.
Q: Does the "Vision Change" last forever?
A: No. Visual side effects are generally mild and usually disappear within 30 to 60 minutes after the infusion ends or after the first week of treatment.
Q: Is it safe for children?
A: Yes, for children aged 2 years and older. The dose is strictly calculated by the pediatrician based on the child's body weight.
Authentic Vfend 200mg (by Pfizer) is supplied by Sanlive Pharmacy to registered hospitals and intensive care units. We ensure that our specialized antifungals are stored under optimal conditions to guarantee potency and patient safety during critical care.
Authentic Pfizer (Original) hospital-grade stock.
Expert clinical support for reconstitution and weight-based dosing.
Licensed pharmacists available for complex drug-interaction screening.
Fast, specialized delivery to medical facilities across Nigeria.
Order Vfend 200mg from Sanlive Pharmacy today for professional-grade, life-saving fungal infection control.
No reviews yet.
Login to write a review.
Related Products
.jpg)
.jpg)
